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Studies on the mechanism by which sulindac sensitizes cancer cells to oxidative stress

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Date Issued:
2011
Summary:
Sulindac is a known NSAID that has also been shown to have anti-cancer activity that is not related to its ability to inhibit COX 1 and 2. During the past 15 years there have been a large number of studies attempting to elucidate its mechanism of action. Our laboratory has shown that sulindac can both protect normal cells and enhance the killing of cancer cells under oxidative stress from H2O2 and TBHP. However, except for mitochondrial dysfunction and ROS production, the mechanism by which sulindac sensitized the cancer cells to oxidative stress remains unknown. Results of this research project suggest that the effect of sulindac and oxidative stress not only involves mitochondrial ROS production, but also aspects of the preconditioning response. In normal cells this leads to survival by a preconditioning pathway, likely involving PKCε. . However, cancer cells react by initiating a pathway leading to apoptosis involving PKCδ.
Title: Studies on the mechanism by which sulindac sensitizes cancer cells to oxidative stress.
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Name(s): Kreymerman, Alexander
Charles E. Schmidt College of Science
Department of Biological Sciences
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Issued: 2011
Publisher: Florida Atlantic University
Physical Form: electronic
Extent: ix, 65 p. : ill. (some col.)
Language(s): English
Summary: Sulindac is a known NSAID that has also been shown to have anti-cancer activity that is not related to its ability to inhibit COX 1 and 2. During the past 15 years there have been a large number of studies attempting to elucidate its mechanism of action. Our laboratory has shown that sulindac can both protect normal cells and enhance the killing of cancer cells under oxidative stress from H2O2 and TBHP. However, except for mitochondrial dysfunction and ROS production, the mechanism by which sulindac sensitized the cancer cells to oxidative stress remains unknown. Results of this research project suggest that the effect of sulindac and oxidative stress not only involves mitochondrial ROS production, but also aspects of the preconditioning response. In normal cells this leads to survival by a preconditioning pathway, likely involving PKCε. . However, cancer cells react by initiating a pathway leading to apoptosis involving PKCδ.
Identifier: 754932606 (oclc), 3183124 (digitool), FADT3183124 (IID), fau:3704 (fedora)
Note(s): by Alexander Kreymerman.
Thesis (M.S.)--Florida Atlantic University, 2011.
Includes bibliography.
Electronic reproduction. Boca Raton, Fla., 2011. Mode of access: World Wide Web.
Subject(s): Proteins -- Chemical modification
Cellular signal transduction
Biochemical markers -- Diagnostic use
Drug resistance in cancer cells
Oxidation-reduction reaction
Persistent Link to This Record: http://purl.flvc.org/FAU/3183124
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU