You are here
Do The Dynamics of Insulin Delivery Matter for Management of Diabetes Mellitus? Evidence From Molecular Measures in a Diabetic Rat Model.
| Title: | Do The Dynamics of Insulin Delivery Matter for Management of Diabetes Mellitus? Evidence From Molecular Measures in a Diabetic Rat Model. |
 80 views 17 downloads |
|---|---|---|
| Name(s): |
Reis, Danielle Tuller, Betty, Thesis advisor Florida Atlantic University, Degree grantor |
|
| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2007 | |
| Date Issued: | 2007 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 34 p. | |
| Language(s): | English | |
| Summary: | The current study uses a diabetic rat model to measure the effects of pulsatile versus continuous insulin delivery on IRS-2 in the liver. The purpose is to determine if pulsatile, compared with continuous, insulin delivery leads to reduced insulin resistance in diabetic rats. Insulin signaling in the liver is mediated primarily through IRS-2 and tissue responsiveness to insulin may be detected by monitoring the lRS-2 signaling pathway. Western blots were performed to measure IRS-2 protein levels for each delivery condition and treatment day. Results revealed that overall, the pulsatile insulin delivery method showed a significant increase in IRS-2 levels over the continuous insulin delivery method by treatment day 5. These findings imply that the pulsatile delivery method, over a period of time, triggers more insulin receptor action. Conversely, the results of the continuous delivery system show a decrease in IRS-2 levels as the number of doses of insulin increased. | |
| Identifier: | FA00000818 (IID) | |
| Degree granted: | Thesis (M.A.)--Florida Atlantic University, 2007. | |
| Note(s): | Charles E. Schmidt College of Science | |
| Subject(s): |
Diabetes--Treatment Rats as laboratory animals Insulin--Receptors |
|
| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00000818 | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
