You are here
Carbohydrate Recognition of Bi-pyridine Bridged Peptide Receptor
| Title: | Carbohydrate Recognition of Bi-pyridine Bridged Peptide Receptor. |
 75 views 15 downloads |
|---|---|---|
| Name(s): |
Johnson, Claudia A. Cudic, Predrag, Thesis advisor Florida Atlantic University, Degree grantor Charles E. Schmidt College of Science Department of Chemistry and Biochemistry |
|
| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2007 | |
| Date Issued: | 2007 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, FL | |
| Physical Form: | application/pdf | |
| Extent: | 106 p. | |
| Language(s): | English | |
| Summary: | A novel carbohydrate receptor based on the structure of the antibiotic polymxin B was synthesized. The receptor was a cyclic heptapeptide. which was bridged using 2, 2'-bi pyridine-5,5"- dicarboxylic acid. The association constants of the receptor and a variety of sugars were determined using UV /Vis and fluorescence spectroscopy and observed log K0 values are in the range from 3 .8 to 4.1 for the pentoses, logKa 3.3 to 3.8 for the hexoxes and 0 to 2.9 logKa values from 0-2.9 for disaccharides and logKa of2.6 to 3.11 for the charged sugars. We demonstrated that polymixin based receptors are capable of binding various monosaccharide substrates in aqueous media, displaying structure selectivity with respect to monosaccharide ring size. | |
| Identifier: | FA00000776 (IID) | |
| Degree granted: | Thesis (M.S.)--Florida Atlantic University, 2007. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): |
Includes bibliography. Charles E. Schmidt College of Science |
|
| Subject(s): |
Protein engineering Neuropeptides--Receptors Chemistry, Organic Cellular recognition |
|
| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00000776 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
