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Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis
- Date Issued:
- 2008
- Summary:
- Fibropapillomatosis (FP) is a devastating pandemic characterized by benign cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to survive. HSP72 and GRP96 are also known to initiate an immune response and may contribute to the regression often observed in FP tumors. Results were found that showed all three protective proteins had significantly higher levels in actively growing tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to be actively growing, were found to have higher levels of HSP72 and GRP96 compared to healthy skin, whereas smooth tumors, thought to be regressing, did not. These results offer insight into the molecular mechanisms behind the development of FP tumors and open a number of avenues for future research.
Title: | Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis. |
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Name(s): |
Deming, Alissa C. Milton, Sarah L., Thesis advisor Florida Atlantic University, Degree grantor |
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Type of Resource: | text | |
Genre: | Electronic Thesis Or Dissertation | |
Date Created: | 2008 | |
Date Issued: | 2008 | |
Publisher: | Florida Atlantic University | |
Place of Publication: | Boca Raton, Fla. | |
Physical Form: | application/pdf | |
Extent: | 78 p. | |
Language(s): | English | |
Summary: | Fibropapillomatosis (FP) is a devastating pandemic characterized by benign cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to survive. HSP72 and GRP96 are also known to initiate an immune response and may contribute to the regression often observed in FP tumors. Results were found that showed all three protective proteins had significantly higher levels in actively growing tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to be actively growing, were found to have higher levels of HSP72 and GRP96 compared to healthy skin, whereas smooth tumors, thought to be regressing, did not. These results offer insight into the molecular mechanisms behind the development of FP tumors and open a number of avenues for future research. | |
Identifier: | FA00000740 (IID) | |
Collection: | FAU Electronic Theses and Dissertations Collection | |
Note(s): |
Includes bibliography. Thesis (M.S.)--Florida Atlantic University, 2008. Charles E. Schmidt College of Science |
|
Subject(s): |
Stress (Physiology) Green turtle--Diseases Environmental monitoring Green turtle--Immunology |
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Held by: | Florida Atlantic University Libraries | |
Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00000740 | |
Sublocation: | Digital Library | |
Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
Host Institution: | FAU | |
Is Part of Series: | Florida Atlantic University Digital Library Collections. |