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Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis

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Date Issued:
2008
Summary:
Fibropapillomatosis (FP) is a devastating pandemic characterized by benign cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to survive. HSP72 and GRP96 are also known to initiate an immune response and may contribute to the regression often observed in FP tumors. Results were found that showed all three protective proteins had significantly higher levels in actively growing tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to be actively growing, were found to have higher levels of HSP72 and GRP96 compared to healthy skin, whereas smooth tumors, thought to be regressing, did not. These results offer insight into the molecular mechanisms behind the development of FP tumors and open a number of avenues for future research.
Title: Stress Protein and Anti-Apoptotic Protein Expression in Green Turtle (Chelonia mydas) Fibropapillomatosis.
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Name(s): Deming, Alissa C.
Milton, Sarah L., Thesis advisor
Florida Atlantic University, Degree grantor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Created: 2008
Date Issued: 2008
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 78 p.
Language(s): English
Summary: Fibropapillomatosis (FP) is a devastating pandemic characterized by benign cutaneous neoplasias that is afflicting marine turtles worldwide. This study evaluated the expression of HSP72, GRP96, and Bcl-2 in tumor and healthy biopsies. These proteins are found in high levels in some tumors and prevent apoptosis, allowing tumor cells to survive. HSP72 and GRP96 are also known to initiate an immune response and may contribute to the regression often observed in FP tumors. Results were found that showed all three protective proteins had significantly higher levels in actively growing tumor tissue compared to healthy tissue. Specifically, cauliflower-like tumors, thought to be actively growing, were found to have higher levels of HSP72 and GRP96 compared to healthy skin, whereas smooth tumors, thought to be regressing, did not. These results offer insight into the molecular mechanisms behind the development of FP tumors and open a number of avenues for future research.
Identifier: FA00000740 (IID)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2008.
Charles E. Schmidt College of Science
Subject(s): Stress (Physiology)
Green turtle--Diseases
Environmental monitoring
Green turtle--Immunology
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00000740
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.