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Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology

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Date Issued:
2008
Summary:
In this thesis I studied propensity for behavioral sensitization to nicotine in the LRHR phenotype and associated plasticity in the hippocampal mossy fiber morphology. I also investigated therapeutic effects of bupropion and a cannabinoid receptor antagonist on behavioral and morphological indices in adolescence and adulthood. Male rats were classified into high responders (HR) and low responders (LR) based on their locomotor response to a novel environment. LRHR animals underwent behavioral sensitization to nicotine and after one week of abstinence were challenged with a low dose of nicotine. HRs expressed behavioral sensitization to nicotine and showed an increase in hippocampal mossy fiber terminal field size. AM251 administration during abstinence reversed behavioral sensitization in HRs and bupropion only attenuated the locomotor response to na"ive nicotine exposure. Therapeutic agents had differential effects on mossy fiber morphology dependent on phenotype and age.
Title: Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology.
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Name(s): Bhatti, Amrinder S.
lsgor, Ceylan, Thesis advisor
Florida Atlantic University, Degree grantor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Created: 2008
Date Issued: 2008
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 100 p.
Language(s): English
Summary: In this thesis I studied propensity for behavioral sensitization to nicotine in the LRHR phenotype and associated plasticity in the hippocampal mossy fiber morphology. I also investigated therapeutic effects of bupropion and a cannabinoid receptor antagonist on behavioral and morphological indices in adolescence and adulthood. Male rats were classified into high responders (HR) and low responders (LR) based on their locomotor response to a novel environment. LRHR animals underwent behavioral sensitization to nicotine and after one week of abstinence were challenged with a low dose of nicotine. HRs expressed behavioral sensitization to nicotine and showed an increase in hippocampal mossy fiber terminal field size. AM251 administration during abstinence reversed behavioral sensitization in HRs and bupropion only attenuated the locomotor response to na"ive nicotine exposure. Therapeutic agents had differential effects on mossy fiber morphology dependent on phenotype and age.
Identifier: FA00000727 (IID)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Includes bibliography.
Dissertation (Ph.D.)--Florida Atlantic University, 2008.
Charles E. Schmidt College of Medicine
Subject(s): Rats as laboratory animals
Risk-taking (Psychology)
Habituation (Neuropsychology)
Personality--Physiological aspects
Nicotine--Physiological effect
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00000727
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.