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Using C. elegans as a Model System to Discover Antiepileptic Drugs

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Date Issued:
2016
Summary:
Novel antiepileptic drugs (AEDs) are commonly tested using rats and mice as model systems. These animals, however, require a great deal of time, money, and lab space to maintain. In contrast, the nematode Caenorhabditis elegans (C. elegans) potentially can provide a faster, and less expensive model system for testing AEDs. C. elegans are simple to maintain and have a very short generation time, allowing high throughput assays to screen for new AEDs. For my thesis research, I used C. elegans to test FDA approved AEDs. My tests support the contention that C. elegans can be a useful model system for AED discovery.
Title: Using C. elegans as a Model System to Discover Antiepileptic Drugs.
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Name(s): Merritt, Mckenzie D.
Wetterer, James K.
Harriet L. Wilkes Honors College
Type of Resource: text
Genre: Thesis
Date Created: Spring 2016
Date Issued: 2016
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: pdf
Extent: 21 p.
Language(s): English
Summary: Novel antiepileptic drugs (AEDs) are commonly tested using rats and mice as model systems. These animals, however, require a great deal of time, money, and lab space to maintain. In contrast, the nematode Caenorhabditis elegans (C. elegans) potentially can provide a faster, and less expensive model system for testing AEDs. C. elegans are simple to maintain and have a very short generation time, allowing high throughput assays to screen for new AEDs. For my thesis research, I used C. elegans to test FDA approved AEDs. My tests support the contention that C. elegans can be a useful model system for AED discovery.
Identifier: FA00003682 (IID)
Note(s): Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2016.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00003682
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Host Institution: FAU

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