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Evaluating The Kinetics Of Proinflammatory Immune Responses To Simian Immunodeficiency Virus Infection In Rhesus Macaques By Transcriptional Analysis
| Title: | Evaluating The Kinetics Of Proinflammatory Immune Responses To Simian Immunodeficiency Virus Infection In Rhesus Macaques By Transcriptional Analysis. |
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| Name(s): |
Cartwright, Michael, author Cameron, Mark, Thesis advisor Narayanan, Ramaswamy, Thesis advisor Florida Atlantic University, Degree grantor Charles E. Schmidt College of Science Department of Biological Sciences |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2016 | |
| Date Issued: | 2016 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 129 p. | |
| Language(s): | English | |
| Summary: | Understanding the host response immediately following mucosal HIV-1 infection will be pivotal in determining whether the immune response induced by a vaccine will successfully sense and control viral replication. In order for effective vaccine strategies and modalities to be developed, these earliest immunological events must be fully assessed in a non-biased manner. Nonhuman primates (NHP), specifically Rhesus macaques (RM), serve as a model to investigate the immunological landscape immediately post-challenge and to define the spatiotemporal path of simian immunodeficiency virus (SIV). SIV infection of RM serves as a model of human HIV infection as it recapitulates many of the virological, immunological, and pathological features of HIV infection in the human host. In this thesis I will test the hypothesis whether transcriptional analysis will allow a sensitive measure of the early innate immune responses that accompany detection of the SIV virus in the periphery. I have determined that an early inflammatory profile arises early in tissues proximal to the challenge site that precedes widespread immune activation and the systemic antiviral interferon response. This study defines in detail the spatiotemporal relationship between virus and host immune response and may be a valuable resource in guiding future vaccine design strategies. | |
| Identifier: | FA00004574 (IID) | |
| Degree granted: | Thesis (M.S.)--Florida Atlantic University, 2016. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Rhesus monkeys. Monkeys as laboratory animals. Retrovirus infections. Veterinary virology. Simian immunodeficiency virus--Immunology. HIV infections--Immunology. AIDS (Disease) HIV (Viruses) Metaphor--Data processing. Language and languages--Political aspects--United States. |
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| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Links: | http://purl.flvc.org/fau/fd/FA00004574 | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00004574 | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
