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Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
| Title: | Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp. |
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| Name(s): |
Paterson, Ian Dalby, S. M. Roberts, J. C. Naylor, G. J. Guzman, Esther A. Isbrucker, Richard A. Pitts, Tara P. Linley, P. A. Divlianska, D. B. Reed, John K. Wright, Amy E. |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2011 | |
| Publisher: | Wiley | |
| Place of Publication: | Weinheim, Germany | |
| Physical Form: | ||
| Extent: | 6 p. | |
| Language(s): | English | |
| Identifier: | FA00007465 (IID), 10.1002/anie.201007719 (doi) | |
| Note(s): |
Leiodermatolide is a structurally unique macrolide isolated from the deep-water marine sponge Leiodermatium sp. which exhibits potent antiproliferative activity against a range of human cancer cell lines and drastic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational NMR methods. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1825 This manuscript is an author version with the final publication available at http://onlinelibrary.wiley.com/ and may be cited as: Paterson, I., Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzmán, E. A., Isbrucker, R., Pitts, T. P., Linley, P., Divlianska, D., Reed, J. K., & Wright, A. E. (2011). Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp. Angewandte Chemie International Edition, 50(14), 3219-3223. doi: 10.1002/anie.201007719 |
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| Subject(s): |
Antimitotic Agents Macrolides Sponges Molecular structure Nuclear Magnetic Resonance, Biomolecular Cell lines |
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| Links: | http://dx.doi.org/10.1002/anie.201007719 | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007465 | |
| Host Institution: | FAU |
