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The discovery and characterization of an interleukin 6 cytokine familyantagonist protein from a marine sponge, Callyspongia sp.
| Title: | The discovery and characterization of an interleukin 6 cytokine familyantagonist protein from a marine sponge, Callyspongia sp. |
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| Name(s): |
Peppard, J. V. Loo, P. Sills, Matthew A. Wennogle, L. Wright, Amy E. Pomponi, Shirley A. Cueto, M. |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2001 | |
| Publisher: | Kluwer Academic | |
| Place of Publication: | New York, NY | |
| Physical Form: | ||
| Extent: | 12 p. | |
| Language(s): | English | |
| Identifier: | FA00007313 (IID), 10.1007/978-1-4615-1291-2_8 (doi) | |
| Note(s): |
The process of drug discovery in the pharmaceutical industry often begins with thesetting up of a bioassay whereby many thousands of synthetic compounds, or lesscharacterized substances such as natural product extracts, may be screened in highthroughput mode. During the early 1990s, we started a search using this approach forinhibitors of the cytokine lnterleukin 6 (IL-6). One of the sources for screening was extracts of marine organisms provided to the former Ciba-Geigy organization by HarborBranch Oceanographic Institute (HBOI). This chapter describes the finding of activityinhibiting IL-6 function from an extract of the marine sponge Callyspongia sp., andwork which was carried out during the effort to characterize this activity more fully. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1315 This manuscript is an author version with the final publication available and may be cited as: Peppard, J. V., Loo, P., Sills, M. A., Wennogle, L., Wright, A., Pomponi, S., & Cueto, M. (2001). The discovery and characterization of an interleukin 6 cytokine family antagonist protein from a marine sponge, Callyspongia sp. In G. Beck, M. Sugumaran, & E. L. Cooper (Eds.), Phylogenetic perspectives on the vertebrate immune system (pp. 77-87). New York: Kluwer Academic. |
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| Subject(s): |
Sponges Interleukin-6 Cytokines--antagonists & inhibitors Proteins--chemistry |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007313 | |
| Links: | https://doi.org/10.1007/978-1-4615-1291-2_8 | |
| Host Institution: | FAU |
