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In vitro production of marine-derived antitumor compounds
| Title: | In vitro production of marine-derived antitumor compounds. |
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| Name(s): |
Pomponi, Shirley A. Willoughby, Robin Wright, Amy E. Pecorella, C. Sennett, Susan H. Lopez, Jose V. Samples, Gail A. |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 1998 | |
| Publisher: | Plenum Press | |
| Place of Publication: | New York, NY | |
| Physical Form: | ||
| Extent: | 5 p. | |
| Language(s): | English | |
| Identifier: | FA00007238 (IID), 10.1007/978-1-4757-5983-9_15 (doi) | |
| Note(s): |
The sustainable supply of marine-derived bioactive compounds to meet demands for pre-clinical and clinical evaluation is a major consideration in drug development strategies. It is also a concern to environmental resource managers, particularly since conservation of genetic resources may preclude harvesting as a bulk supply strategy. Our research addresses this need by focusing on in vitro production of antitumor compounds through cell culture of the source organisms. Our objectives are: to establish cultures of bioactive marine invertebrates that can be used as models to study in vitro production of antitumor compounds and the factors which control expression of their production; to provide bulk supplies of these compounds through in vitro production; and to produce new structural analogs via manipulation of culture conditions. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1255 This manuscript is an author version with the final publication available and may be cited as: Pomponi, S. A., Willoughby, R., Wright, A. E., Pecorella, C., Sennett, S. H., Lopez, J., & Samples, G. (1998). In vitro production of marine-derived antitumor compounds. In Y. Le Gal & H. O. Halverson (Eds.), New developments in marine biotechnology (pp. 73-76). New York, NY: Plenum Press. |
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| Subject(s): |
Antineoplastic agents Bioactive compounds Marine natural products In vitro Antitumor agents |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007238 | |
| Links: | https://doi.org/10.1007/978-1-4757-5983-9_15 | |
| Host Institution: | FAU |
