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Bioassay-guided isolation and identification of linoleic acid: A guanosine diphosphate/G-protein RASexchange (GDPX) inhibitor from Aspergillus

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Date Issued:
1995
Title: Bioassay-guided isolation and identification of linoleic acid: A guanosine diphosphate/G-protein RASexchange (GDPX) inhibitor from Aspergillus.
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Name(s): Gunasekera, Sarath P.
Sennett, Susan H.
Janda, Kathleen E.
Bryant, R. W.
Harbor Branch Oceanographic Institute
Type of Resource: text
Genre: Article
Date Issued: 1995
Publisher: Swets & Zeitlinger
Place of Publication: Lisse, Netherlands
Physical Form: pdf
Extent: 4 p.
Language(s): English
Identifier: FA00007232 (IID), 10.3109/13880209509065375 (doi)
Note(s): An extract of an Aspergillus sp. (HBOI strain D245) was found to inhibit guanosine diphosphate/G-protein RAS exchange (GDPX). Bioassay-guided purification led to the isolation of linoleic acid (1). 1 gave significant inhibition in the GDPX assay, while methyl linoleate (2) was inactive. In this paper we report the isolation, identification and biological activity of 1.Read More: http://informahealthcare.com/doi/abs/10.3109/13880209509065375
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1048
This manuscript is an author version with the final publication available and may be cited as: Gunasekera, S. P., Sennett, S. H., Janda, K. E., & Bryant, R. W. (1995). Bioassay-guided isolation and identification of linoleic acid: A guanosine diphosphate/G-protein RAS exchange (GDPX) inhibitor from Aspergillus. International Journal of Pharmacognosy 33(3), 256-258.
Subject(s): Aspergillus
Linoleic acid
Biological Assay
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00007232
Links: http://dx.doi.org/10.3109/13880209509065375
Host Institution: FAU