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Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
| Title: | Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. |
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| Name(s): |
Horton, P. A. Longley, Ross E. Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 1994 | |
| Publisher: | Birkhauser Verlag | |
| Place of Publication: | Basel, Switzerland | |
| Physical Form: | ||
| Extent: | 4 p. | |
| Language(s): | English | |
| Identifier: | FA00007230 (IID), 10.1007/BF01956468 (doi) | |
| Note(s): |
Staurosporine aglycone (K252-c) (compound1) and arcyriaflavin A (2) were isolated from a specimen of the marine ascidian,Eudistoma sp., collected off the coast of West Africa. In addition to expressing micromolar and submicromolar inhibition of enzyme activity against seven protein kinase C isoenzymes and inhibition of proliferation of the human lung cancer A549 and P388 murine leukemia cell lines,1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in the K562 bleb and neutrophil assays. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1022 This manuscript is an author version with the final publication available and may be cited as: Horton, P. A., Longley, R. E., McConnell, O. J., & Ballas, L. M. (1994). Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. Experientia, 50(9), 843-845. |
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| Subject(s): |
Ascidians Sea squirts Protein kinase C Cytotoxins Indoles Carbazoles |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007230 | |
| Links: | http://dx.doi.org/10.1007/BF01956468 | |
| Host Institution: | FAU |
