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Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae
| Title: | Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae. |
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| Name(s): |
McConnell, O. J. Longley, Ross E. Gunasekera, M. Harbor Branch Oceanographic Institute |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 1992 | |
| Publisher: | Birkhauser Verlag | |
| Place of Publication: | Basel, Switzerland | |
| Physical Form: | ||
| Extent: | 3 p. | |
| Language(s): | English | |
| Identifier: | FA00007220 (IID) | |
| Note(s): |
Isometachromin (1), a new sesquiterpene-quinone that is related structurally to metachromin C (2), and the known compounds ilimaquinone (3) and 5-epi-ilimaquinone (4), were isolated from a deep water sponge in the family Spongiidae; the structure of isometachromin was elucidated by spectral methods. Isometachromin exhibits in vitro cytotoxicity against the human lung cancer cell line A549 (IC50 = 2.6 micrograms/ml), but not against P388 murine leukemia (IC 50 > or equal to 10 micrograms/ml) and also exhibits antimicrobial activity. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 911 This manuscript is an author version with the final publication available and may be cited as: McConnell, O. J., Longley, R., & Gunasekera, M. (1992). Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae. Experientia, 48(9), 891-892. |
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| Subject(s): |
Sponges Sesquiterpenes Cytotoxins Porifera |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007220 | |
| Host Institution: | FAU |
