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The Impact of Obesity on Plasma Calprotectin in Response to Acute Aerobic Exercise

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Date Issued:
2015
Summary:
The secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following exercise, and one hour after exercise. Our results showed higher baseline levels of calprotectin in obese subjects than normal-weight subjects. While acute aerobic exercise increased an elevation in calprotectin and IL-6, no difference was found between two groups. Furthermore, a positive relationship was observed between calprotectin area-under-the curve “with respect to increase” (AUCi) and IL-6 AUCi, even after controlling for cardiorespiratory fitness (VO2max). Our results support previous finding that IL-6 may potentially regulate calprotectin expression in skeletal muscle during exercise.
Title: The Impact of Obesity on Plasma Calprotectin in Response to Acute Aerobic Exercise.
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Name(s): Fico, Brandon G.
Slusher, Aaron L.
Whitehurst, Michael
Maharaj, Arun
Huang, Chun-Jung
College of Education
Type of Resource: text
Genre: Poster
Date Issued: 2015
Publisher: Florida Atlantic University Libraries: Digital Library
Physical Form: pdf
Extent: 1 p.
Language(s): English
Summary: The secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following exercise, and one hour after exercise. Our results showed higher baseline levels of calprotectin in obese subjects than normal-weight subjects. While acute aerobic exercise increased an elevation in calprotectin and IL-6, no difference was found between two groups. Furthermore, a positive relationship was observed between calprotectin area-under-the curve “with respect to increase” (AUCi) and IL-6 AUCi, even after controlling for cardiorespiratory fitness (VO2max). Our results support previous finding that IL-6 may potentially regulate calprotectin expression in skeletal muscle during exercise.
Identifier: FA00005187 (IID)
Subject(s): College students --Research --United States.
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00005187
Host Institution: FAU