You are here
Mechanisms of Placental Dysfunction in Pregnancy Malaria
| Title: | Mechanisms of Placental Dysfunction in Pregnancy Malaria. |
 81 views 27 downloads |
|---|---|---|
| Name(s): |
Lybbert, Jared, author Oleinikov, Andrew V., Thesis advisor Florida Atlantic University, Degree grantor Charles E. Schmidt College of Medicine Department of Biomedical Science |
|
| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2015 | |
| Date Issued: | 2015 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 39 p. | |
| Language(s): | English | |
| Summary: | The molecular mechanisms by which pregnancy malaria affects the outcome of fetal development are unknown. Megalin, which has been well studied in kidney, has high expression in the placenta from early stages to term, and is proposed to be an important factor in extensive maternofetal exchange during development of the fetus. Pregnancy malaria (PM) is characterized by inflammation in placenta and is associated with low birthweight (LBW), stillborn birth, and other pathologies. It is hypothesized that PM disturbs megalin function/expression/distribution in the brush boarder of syncytiotrophoblast which, in turn, may contribute significantly to pathology of LBW. Our studies show that the presence of infected erythrocytes in placenta at the time of delivery negatively affects protein abundance for megalin and Dab2. This is the first report associating the abundance of placental megalin system proteins with the birth weight of newborn babies, and associating PM with changes in megalin system protein abundance. | |
| Identifier: | FA00004520 (IID) | |
| Degree granted: | Thesis (M.S.)--Florida Atlantic University, 2015. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Birth weight, Low Critical care medicine Fetus -- Diseases -- Molecular diagnosis Pregnancy -- Complications Prenatal diagnosis Stillbirth |
|
| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Links: | http://purl.flvc.org/fau/fd/FA00004520 | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00004520 | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
