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RESPONSES OF A CALCIUM CHANNEL MODELTO VARIATIONS IN VOLTAGE WAVEFORM

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Date Issued:
2014
Summary:
Action potential repolarization in certain neurons slows at neurotransmitter release sites in the axon if an action potential is preceded by sufficient depolarization. We hypothesize that slower repolarization allows axons to change strength of neurotransmission by changing calcium channel open probability. This was explored with a Markov model comprised of multiple calcium channel subtypes and an action potential waveform input. The model was solved for channel open probability, channel ionic current and charge from ionic current. The outputted charge from the model was compared to experimental calcium imaging results in neurons from mouse cerebellum. The results show that more calcium flows into the cell when the action potential is widened. This implies that in some neurons, a wider action potential may lead to opening of calcium channels that respond selectively to the duration of the action potential waveform at sites of release.
Title: RESPONSES OF A CALCIUM CHANNEL MODELTO VARIATIONS IN VOLTAGE WAVEFORM.
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Name(s): Tranquil, Elizabeth
Christie, Jason
Kirchman, Paul
Kundalkar, Shree
Harriet L. Wilkes Honors College
Type of Resource: text
Genre: Thesis
Date Created: Spring 2014
Date Issued: 2014
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: pdf
Extent: 53 p.
Language(s): English
Summary: Action potential repolarization in certain neurons slows at neurotransmitter release sites in the axon if an action potential is preceded by sufficient depolarization. We hypothesize that slower repolarization allows axons to change strength of neurotransmission by changing calcium channel open probability. This was explored with a Markov model comprised of multiple calcium channel subtypes and an action potential waveform input. The model was solved for channel open probability, channel ionic current and charge from ionic current. The outputted charge from the model was compared to experimental calcium imaging results in neurons from mouse cerebellum. The results show that more calcium flows into the cell when the action potential is widened. This implies that in some neurons, a wider action potential may lead to opening of calcium channels that respond selectively to the duration of the action potential waveform at sites of release.
Identifier: FA00003630 (IID)
Note(s): Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2014.
Held by: Florida Atlantic University Libraries
Sublocation: Digital Library
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00003630
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Host Institution: FAU

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