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Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines
| Title: | Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines. |
 115 views 44 downloads |
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| Name(s): |
Guzman, Esther A. Johnson, J. D. Carrier, M. K. Meyer, C. I. Pitts, Tara P. Gunasekera, Sarath P. Wright, Amy E. |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2009 | |
| Publisher: | Lippincott, Williams & Wilkins | |
| Place of Publication: | Philadelphia | |
| Physical Form: | ||
| Extent: | 8 p. | |
| Language(s): | English | |
| Identifier: | FA00007114 (IID), 10.1097/CAD.0b013e32831fa39e (doi) | |
| Note(s): |
Given our interest in
finding new therapies for pancreatic cancer, we sought to
determine whether the known cytotoxic activity of the
batzellines extended to pancreatic cancer cell lines. The
batzellines are pyrroloiminoquinones alkaloids obtained
from the deep-water Caribbean sponge Batzella sp (family
Esperiopsidae, order Poecilosclerida). We show here that
batzellines exhibit selective cytotoxicity towards the
pancreatic cancer cell lines AsPC-1, Panc-1, BxPC-3, and
MIA PaCa2 compared with the normal African green
monkey kidney epithelial cell line Vero. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1715 This manuscript is an author version with the final publication available and may be cited as: Guzman, E. A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, T. P., Gunasekera, S. P., & Wright, A. E. (2009). Selective cytotoxic activity of the marine derived batzelline compounds against pancreatic cancer cell lines. Anti-Cancer Drugs, 20(2), 149-155. doi:10.1097/CAD.0b013e32831fa39e |
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| Subject(s): |
Pancreas--Cancer Marine natural products Drug Discovery Sponges--Caribbean Sea Mechanism of action (Biochemistry) |
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| Links: | http://dx.doi.org/10.1097/CAD.0b013e32831fa39e | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007114 | |
| Host Institution: | FAU |
