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Early effects of Lasonolide A on pancreatic cancer cells
| Title: | Early effects of Lasonolide A on pancreatic cancer cells. |
 115 views 33 downloads |
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| Name(s): |
Isbrucker, Richard A. Guzman, Esther A. Pitts, Tara P. Wright, Amy E. |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2000 | |
| Publisher: | American Society for Pharmacology and Experimental Therapeutics | |
| Place of Publication: | Baltimore, MD | |
| Physical Form: | ||
| Extent: | 8 p. | |
| Language(s): | English | |
| Identifier: | FA00007053 (IID), 10.1124/jpet.109.155531 (doi) | |
| Note(s): |
Lasonolide A, a novel polyketide-derived macrolide, was previously identified from an extract of the marine sponge Forcepia sp. in an assay for protein kinase C (PKC) inhibitors. Cytotoxicity testing and profiling of lasonolide A in the National Cancer Institute (NCI) 60 cell panel screen revealed that it was potent toward a broad range of cell lines and also suggested a unique mechanism of action. Contrary to expected results, we found lasonolide A to be a strong activator of PKC in Panc-1 pancreatic carcinoma cells. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1785 This manuscript is an author version with the final publication available and may be cited as: Isbrucker, R. A., Guzman, E. A., Pitts, T. P., & Wright, A. E. (2009). Early effects of Lasonolide A on pancreatic cancer cells. Journal of Pharmacology and Experimental Therapeutics, 331(2), 733-739. |
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| Subject(s): |
Macrolides Sponges Marine natural products Pancreatic Neoplasms Pancreas--Cancer |
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| Links: | http://dx.doi.org/10.1124/jpet.109.155531 | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007053 | |
| Host Institution: | FAU |
