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Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
| Title: | Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. |
 127 views 25 downloads |
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| Name(s): |
Paterson, Ian Naylor, G. J. Wright, Amy E. |
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| Type of Resource: | text | |
| Genre: | Article | |
| Date Issued: | 2008 | |
| Publisher: | Royal Society of Chemistry | |
| Place of Publication: | Cambridge | |
| Physical Form: | ||
| Extent: | 4 p. | |
| Language(s): | English | |
| Identifier: | FA00007062 (IID), 10.1039/b811575c (doi) | |
| Note(s): |
A potent dictyostatin–discodermolide hybrid was designed and synthesised; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line. Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1776 This manuscript is an author version with the final publication available and may be cited as: Paterson, I., Naylor, G. J., & Wright, A. E. (2008). Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide. Chemical Communications, 38, 4628-4630. doi:10.1039/b811575c |
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| Subject(s): |
Antineoplastic agents Macrolides Polyketides Tubulin Modulators Marine natural products Sponges |
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| Links: | http://dx.doi.org/doi:10.1039/b811575c | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00007062 | |
| Host Institution: | FAU |
