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Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus)
| Title: | Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus). |
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| Name(s): |
Bible, Brittany, author Nouri-Shirazi, Mahyar, Thesis advisor Florida Atlantic University, Degree grantor Charles E. Schmidt College of Medicine Department of Biomedical Science |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2015 | |
| Date Issued: | 2015 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 129 p. | |
| Language(s): | English | |
| Summary: | Recently, there has been an increase in marine mammal mortalities, most commonly Atlantic bottlenose dolphins, Tursiops truncatus, which is an alarming indication of the health status of the marine ecosystem. Studies have demonstrated that some free-ranging dolphins exhibit a suppressed immune system possibly because of exposure to contaminants or infectious microorganisms. However, this research has been limited due to a lack of commercially available marine-specific antibodies. Therefore, the first chapter of this thesis aims to identify cross-reactive terrestrial-specific antibodies that could be used to phenotype and compare the immune cell populations of dolphins under human care and free-ranging dolphins. The second chapter aims to utilize terrestrial-specific growth factors and dendritic cell (DC) surface markers to generate, characterize, and compare ex vivo DCs from peripheral blood mononuclear cells (PBMCs) of dolphins under human care and free-ranging dolphins. In summary, I have identified differences within the PBMCs and ex vivo generated DCs of dolphins under human care and free-ranging dolphins that could potentially shed light on the impact of environmental contaminants and infectious microorganisms on immune cells which could lead to increased morbidity and mortality. | |
| Identifier: | FA00004347 (IID) | |
| Degree granted: | Dissertation (Ph.D.)--Florida Atlantic University, 2015. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Bottlenose dolphin -- Physiology Dolphins -- Physiology Marine animals -- North Atlantic Ocean -- Identification. Marine mammals -- Atlantic Coast (U.S.) Marine mammals -- Effect of water pollution on Marine mammals -- North Atlantic Ocean -- Identification |
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| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Links: | http://purl.flvc.org/fau/fd/FA00004347 | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00004347 | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
