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effect of ambient temperature on serotonin syndrome
| Title: | The effect of ambient temperature on serotonin syndrome. |
 199 views 88 downloads |
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| Name(s): |
Krishnamoorthy, Swapna. Charles E. Schmidt College of Medicine |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 2008 | |
| Publisher: | Florida Atlantic University | |
| Physical Form: | electronic | |
| Extent: | xiv, 168 p. : ill. (some col.). | |
| Language(s): | English | |
| Summary: | Serotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and prefrontal cortex (PFC), in particular, are sensitive to changes in ambient temperature (Tamb). The toxic increase of 5-HT is postulated to occur due to the temperature-dependent activation of these receptors that promotes a positive feedback mechanism. Our results suggest that changes in Tamb can either exacerbate or alleviate the symptom and that this is mediated by the 5-HT2A receptors. Understanding the mechanism involved in elevating Tcor is imperative in treating and preventing the disorder. | |
| Identifier: | 317858074 (oclc), 186297 (digitool), FADT186297 (IID), fau:2864 (fedora) | |
| Note(s): |
by Swapna Krishnamoorthy. Vita. Thesis (M.S.)--Florida Atlantic University, 2008. Includes bibliography. Electronic reproduction. Boca Raton, Fla., 2008. Mode of access: World Wide Web. |
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| Subject(s): |
Serotoninergic mechanisms Central nervous system -- Physiology Body temperature -- Regulation Neurotransmitter receptors Serotonin -- Physiological effect |
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| Held by: | FBoU FAUER | |
| Persistent Link to This Record: | http://purl.flvc.org/FAU/186297 | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
