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Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning
| Title: | Loss of tolerance to amphetamine-induced hypophagia in rats: homeostatic readjustment vs. instrumental learning. |
 101 views 38 downloads |
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| Name(s): |
Wolgin, David L., creator Hughes, Katherine M., creator Popi, Lavinia, creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1999-09 | |
| Publisher: | Elsevier B.V. | |
| Language(s): | English | |
| Identifier: | 228632 (digitool), FADT228632 (IID), fau:2633 (fedora), 10.1016/S0091-3057(99)00112-4 (doi) | |
| FAU Department/College: | Department of Psychology Charles E. Schmidt College of Science | |
| Note(s): |
According to the homeostatic model, the loss of tolerance to amphetamine-induced hypophagia requires a period of unrestricted feeding in the drug-free state, which transforms the compensatory response mediating tolerance (”hyperhunger”) into a functional disturbance to homeostasis. In the absence of such a disturbance, tolerance should be retained. To test this prediction, rats tolerant to amphetamine's hypophagic effect were given a 4-week tolerance retention period during which milk intakes were restricted and deprivation levels held relatively constant. This manuscript is a version of an article published in Pharmacology Biochemistry and Behaviorv. 64, no. 1(September 1999) p.177-182 available at http://www.sciencedirect.com/ |
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| Subject(s): |
Psychopharmacology--Research. Appetite depressants. Amphetamines--Physiological effects. |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/228632 | |
| Links: | http://dx.doi.org/10.1016/S0091-3057(99)00112-4 | |
| Restrictions on Access: | ©1999 Elsevier Science, Inc. | |
| Host Institution: | FAU |
