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Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia
| Title: | Role of behavioral and pharmacological variables in the loss of tolerance to amphetamine hypophagia. |
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| Name(s): |
Wolgin, David L., creator Hughes, Katherine M., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1997-08-01 | |
| Publisher: | Springer-Verlag | |
| Language(s): | English | |
| Identifier: | 228486 (digitool), FADT228486 (IID), fau:2627 (fedora), 10.1007/s002130050354 (doi) | |
| FAU Department/College: | Department of Psychology Charles E. Schmidt College of Science | |
| Note(s): |
Tolerance to amphetamine-induced hypophagia is lost when drug injections are withdrawn for 4 weeks while milk tests are continued (Wolgin and Hughes 1996). The purpose of this study was to determine whether the loss of tolerance is a function of drug withdrawal per se. Rats made tolerant to amphetamine (2 mg/kg, IP) were assigned to one of three groups. During the next 4 weeks (phase), one group continued to receive amphetamine injections prior to daily milk tests (Before group), one group received drug injections after the milk tests (After group), and one group received injections of saline prior to the milk tests (Saline group). Dose-response tests revealed that the Before group retained tolerance, whereas the After and Saline groups lost tolerance. This manuscript is a version of an article published in Psychopharmacology (1997) 132:342–349. The original publication is available at www.springerlink.com |
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| Subject(s): |
Psychopharmacology--Research. Amphetamines--Physiological effects. |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/228486 | |
| Links: | http://dx.doi.org/10.1007/s002130050354 | |
| Restrictions on Access: | ©1997 Springer Berlin / Heidelberg | |
| Host Institution: | FAU |
