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Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia
| Title: | Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia. |
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| Name(s): |
Wolgin, David L., creator Kinney, Gene G., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1992 | |
| Publisher: | American Society for Pharmacology and Experimental Therapeautics | |
| Language(s): | English | |
| Identifier: | FADT226864 (IID), 226864 (digitool), fau:2621 (fedora), 0022.3565/92/2623.1232$03.OO/O (Journal of Pharmacology and Experimental Therapeutics) | |
| FAU Department/College: | Department of Psychology Charles E. Schmidt College of Science | |
| Note(s): |
The purpose of this experiment was to explore the relation between amphetamine-induced stereotyped movements and the development of tolerance to the initial hypophagic effect of the drug. If stereotyped movements contribute to hypophagia, then prior sensitization of stereotypy should exaggerate the initial hypophagic effect and retard the development of tolerance. To test this hypothesis, one group of rats was given intermittent injections of amphetamine (2.5 mg/kg) to induce sensitization, and another group was given saline as a control. Sensitization was characterized by increased head scanning movements and decreased stationary activity, locomotion and sniffing. However, dose-response tests revealed that sensitized rats did not show increased hypophagia in a milk drinking task. This manuscript is a version of an article published in The Journal of Pharmacology and Experimental Therapeutics v. 262, no. 3(1992) p. 1232-1241 http://jpet.aspetjournals.org/content/vol262/issue3/ |
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| Subject(s): |
Psychopharmacology--Research Amphetamines--Physiological effects. |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/226864 | |
| Restrictions on Access: | ©1992 The American Society for Pharmacology and Experimental Therapeutics | |
| Host Institution: | FAU |
