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Fractal ion-channel behavior generates fractal firing patterns in neuronal models
| Title: | Fractal ion-channel behavior generates fractal firing patterns in neuronal models. |
 221 views 142 downloads |
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| Name(s): |
Liebovitch, Larry S., creator Lowen, Steven B., creator White, John A., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1999-05 | |
| Publisher: | The American Physical Society | |
| Language(s): | English | |
| Identifier: | 165477 (digitool), FADT165477 (IID), fau:2607 (fedora), 10.1103/PhysRevE.59.5970 (doi) | |
| FAU Department/College: | Department of Psychology Charles E. Schmidt College of Science | |
| Note(s): |
Fractal behavior has been observed in both ion-channel gating and neuronal spiking patterns, but a causal relationship between the two has not yet been established. Here, the authors examine the effects of fractal ion-channel activity in modifications of two classical neuronal models: Fitzhugh-Nagumo (FHN) and Hodgkin-Huxley (HH). For the modified FHN model, the recovery variable was represented as a population of ion channels with either fractal or Markov gating characteristics. Fractal gating characteristics changed the form of the interspike interval histogram (ISIH) and also induced fractal behavior in the firing rate. For the HH model, the K+ conductance was represented as a collection of ion channels with either quasifractal or Markov gating properties. Fractal gating induced fractal-rate behavior without changing the ISIH. The authors conclude that fractal ion-channel gating activity is sufficient to account for fractal-rate firing behavior. This manuscript is a version of an article published in Physical Review E v. 59, no. 5 (May 1999) p. 5970-5980 http://link.aps.org/doi/10.1103/PhysRevE.59.5970 |
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| Subject(s): |
Biophysics--Research Fractals Neural networks (Neurobiology)--Mathematical models Neurons--Mathematical models Markov processes--Mathematical models Ion channels--Mathematical models |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/165477 | |
| Links: | http://dx.doi.org/10.1103/PhysRevE.59.5970 | |
| Restrictions on Access: | ©1999 The American Physical Society | |
| Host Institution: | FAU |
