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Is there an error correcting code in the base sequence in DNA?

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Date Issued:
Title: Is there an error correcting code in the base sequence in DNA?.
Name(s): Liebovitch, Larry S., creator
Levine, Leo, creator
Tao, Yi, creator
Todorov, Angelo T., creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1996-09
Publisher: The Biophysical Society
Language(s): English
Identifier: FADT165441 (IID), 165441 (digitool), fau:2603 (fedora), 0006-3495/96/09/1539/06 (Biophysical Society)
FAU Department/College: Department of Psychology Charles E. Schmidt College of Science
Note(s): Modern methods of encoding information into digital form include error check digits that are functions of the other information digits. When digital information is transmitted, the values of the error check digits can be computed from the information digits to determine whether the information has been received accurately. These error correcting codes make it possible to detect and correct common errors in transmission. The sequence of bases in DNA is also a digital code consisting of four symbols: A, C, G, and T. Does DNA also contain an error correcting code? Such a code would allow repair enzymes to protect the fidelity of nonreplicating DNA and increase the accuracy of replication. If a linear block error correcting code is present in DNA then some bases would be a linear function of the other bases in each set of bases. The authors have developed an efficient procedure to determine whether such an error correcting code is present in the base sequence. The article illustrates the use of this procedure by using it to analyze the Iac operon and the gene for cytochrome c. These genes do not appear to contain such a simple error correcting code.
This manuscript is a version of an article published in Biophysical Journal v. 71, no. 3 (September 1996) p. 1539-1544
Subject(s): Biophysics--Research
DNA Repair--genetics
DNA--Analysis--Mathematical models
Genetic code
Persistent Link to This Record:
Restrictions on Access: ©1996 The Biophysical Society
Host Institution: FAU

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