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INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men

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Date Issued:
2008-12-23
Title: INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.
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Name(s): Orkunoglu-Suer, Funda E., creator
Gordish-Dressman, Heather, creator
Clarkson, Priscilla M., creator
Thompson, Paul D., creator
Angelopoulos, Theodore J., creator
Gordon, Paul M., creator
Moyna, Niall M., creator
Pescatello, Linda S., creator
Visich, Paul S., creator
Zoeller, Robert F., creator
Harmon, Brennan, creator
Seip, Richard L., creator
Hoffman, Eric P., creator
Devaney, Joseph M., creator
Type of Resource: text
Date Issued: 2008-12-23
Physical Description: text/pdf[9p.]
Language(s): English
Identifier: 3327172 (digitool), FADT3327172 (IID), fau:1944 (fedora), 10.1186/1471‐2350‐9‐117 (doi)
Note(s): Background: A common SNP upstream of the INSIG2 gene, rs7566605 (g.-10,1025G>C,Chr2:118,552,255, NT_022135.15), was reported to be associated with obesity (Body Mass Index,[BMI]) in a genome-wide association scan using the Framingham Heart Study but has not been reproduced in other cohorts. As BMI is a relatively insensitive measure of adiposity that is subject to many confounding variables, we sought to determine the relationship between the INSIG2 SNPand subcutaneous fat volumes measured by MRI in a young adult population.
Subject(s): Adiposity --genetics
Alleles
Gene Frequency
Intracellular Signaling Peptides and Proteins
Resistance Training
Subcutaneous Fat
INSIG2 protein
Obesity
Genotype
Membrane Proteins
Membrane Proteins --Genetics
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/3327172
Host Institution: FAU

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