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Role of taurine in the central nervous system

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Date Issued:
Title: Role of taurine in the central nervous system.
Name(s): Wu, Jang-Yen, creator
Prentice, Howard, creator
Type of Resource: text
Date Issued: 2010-08-24
Physical Form: application/pdf
Extent: 7 p.
Language(s): English
Identifier: 3327262 (digitool), FADT3327262 (IID), fau:1896 (fedora), 10.1186/1423-0127-17-S1-S1 (doi)
Note(s): Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte, as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine transporter system. Taurine exerts its neuroprotective functions against the glutamate induced excitotoxicity by reducing the glutamate-induced increase of intracellular calcium level, by shifting the ratio of Bcl-2 and Bad ratio in favor of cell survival and by reducing the ER stress. The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented.
Subject(s): Central Nervous System --metabolism
Glutamic Acid --metabolism
Homeostasis --physiology
Neuroprotective Agents --metabolism
Neurotransmitter Agents --metabolism
Proto-Oncogene Proteins c-bcl-2 --metabolism
Receptors, Neurotransmitter --metabolism
Signal Transduction --physiology
Taurine --metabolism
Neuroprotective Agents
Neurotransmitter Agents
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Host Institution: FAU

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