You are here
Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse
| Title: | Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse. |
 96 views 26 downloads |
|---|---|---|
| Name(s): |
Mozdzanowska, Krystyna, creator Zharikova, Darya, creator Cudic, Mare, creator Otvos, Laszlo, creator Gerhard, Walter, creator |
|
| Type of Resource: | text | |
| Date Issued: | 2007-10-27 | |
| Physical Description: | text/pdf[15p.] | |
| Language(s): | English | |
| Identifier: | 3327982 (digitool), FADT3327982 (IID), fau:1893 (fedora) | |
| FAU Department/College: | Department of Chemistry and Biochemistry Charles E. Schmidt College of Science | |
| Note(s): | Background: The M2 ectodomain (M2e) of influenza A virus (IAV) strains that have circulated in humans during the past 90 years shows remarkably little structural diversity. Since M2e-specific antibodies (Abs) are capable of restricting IAV replication in vivo but are present only at minimal concentration in human sera, efforts are being made to develop a M2e-specific vaccine. We are exploring a synthetic multiple antigenic peptide (MAP) vaccine and here report on the role of adjuvants (cholera toxin and immunostimulatory oligodeoxynucleotide) and route of immunization on Ab response and strength of protection. | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3327982 | |
| Host Institution: | FAU |
