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Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakenss
| Title: | Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakenss. |
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| Name(s): |
Kim, Chul, creator Srivastava, Sapeckshita, creator Rice, Marian, creator Godenschwege, Tanja A., creator Bentley, Brooke, creator Ravi, Saranya, creator Shao, Shuang, creator Woodard, Craig T., creator Schwartz, Lawrence M., creator |
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| Type of Resource: | text | |
| Date Issued: | 2011-04-25 | |
| Physical Description: | text/pdf[10p.] | |
| Language(s): | English | |
| Identifier: | 3327608 (digitool), FADT3327608 (IID), fau:1890 (fedora), 10.1186/1472-6793-11-7 (doi) | |
| FAU Department/College: | Department of Biological Science Charles E. Schmidt College of Science | |
| Note(s): | Background: One of the hallmarks of Alzheimer’s disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloid peptides. To better understand the pathological consequences of inappropriate APP expression on developing tissues, we generated transgenic flies that express wild-type human APP in the skeletal muscles, andthen performed anatomical, electrophysiological, and behavioral analysis of the adults. | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3327608 | |
| Host Institution: | FAU |
