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Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and β-lapachone combination treatment
| Title: | Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and β-lapachone combination treatment. |
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| Name(s): |
Kumi-Diaka, James, creator Saddler, Shawnette Simone, creator Aller, Alex, creator Brown, Jayann Marie, creator |
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| Type of Resource: | text | |
| Date Issued: | 2004-08-17 | |
| Physical Description: | text/pdf[10p.] | |
| Language(s): | English | |
| Identifier: | 3327156 (digitool), FADT3327156 (IID), fau:1889 (fedora) | |
| FAU Department/College: | Department of Biological Science Charles E. Schmidt College of Science | |
| Note(s): | Background: Prostate cancer is the second leading cause of male death in the United States. The incidence increases most rapidly with age, and multiple genetic and epigenetic factors have been implicatedin the initiation, progression, and metastasis of the cancer. Nevertheless, scientific knowledge of the molecular mechanisms underlying the disease is still limited; and hence treatment has only been partially successful. The objective of the current studies was to examine the role of caspase 3 (CPP32) and NAD(P)H:quinone oxidoreductase (NQO1) in the signaling of genistein-and β-lapachone (bLap)-inducedapoptosis in human prostate carcinoma cells PC3. | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3327156 | |
| Host Institution: | FAU |
