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Cells and cocktails
| Title: | Cells and cocktails: antioxidants rescue carcinogen induced mitotic defects in both chromosomally stable and unstable cells. |
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| Name(s): |
Griffin, Isabel Sloan. Harriet L. Wilkes Honors College |
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| Type of Resource: | text | |
| Genre: | Thesis | |
| Issuance: | multipart monograph | |
| Date Issued: | 2012 | |
| Publisher: | Florida Atlantic University | |
| Physical Form: |
electronic electronic resource |
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| Extent: | vii, 29 p. : ill. | |
| Language(s): | English | |
| Summary: | Tumor cells are characterized by an increase in genomic instability, brought about by both chromosomal rearrangement and chromosomal instability. Both of these broad changes can be induced by exposure to carcinogens. During mitosis, cells can exhibit early and late lagging chromosomes, multipolar spindles or anaphase bridges, all of which contribute to genomic rearrantement. We have studied the link between exposure to carcinogen and prevalence of mitotic defect in both chromosomally stable and unstable cell lines as well as ecamined the restorative effects of antioxidants in preventing mitotic defects. We have exposed MES-SA uterine cancer cells to vinyl chloride followed by exposure to an antioxidant : ascorbic acid, B-carotene, or lycopene. Treated cells were then scored for the prevalence of mitotic defects within the population and compared to controls. We have also investigated whether pre-treatment with the antioxidants will weaken the effects of carcinogen exposure in these cell lines. | |
| Identifier: | 818656732 (oclc), 3359304 (digitool), FADT3359304 (IID), fau:1432 (fedora) | |
| Note(s): |
Isabel Sloan Griffin. Thesis (B.A.)--Florida Atlantic University, Honors College, 2012. Includes bibliography. Electronic reproduction. Boca Raton, Fla., 2012. Mode of access: World Wide Web. |
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| Subject(s): |
Cellular signal transduction Cell differentiation Medical genetics Cancer -- Genetic aspects Antioxidants -- Therapeutic use Cancer -- Chemoprevention Apoptosis -- Molecular aspects Genetic regulation |
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| Held by: | FBoU FAUER | |
| Persistent Link to This Record: | http://purl.flvc.org/FAU/3359304 | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Host Institution: | FAU |
