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Differential effect of sulindac on normal and malignant retinal cells

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Date Issued:
2013
Summary:
Age related macular degeneration (AMD) is the leading cause of blindness among the elderly population and oxidative stress induced damage of ocular tissues is thought to play an important role in the etiology of this disease. This current study is aimed at testing pharmacological preconditioning as a possible protective mechanism for retinal cells against oxidative stress induced damage. Since the retinal pigment epithelial (RPE) cells located adjacent to the photoreceptor cells, are believed to be responsible for the initial pathology in AMD we tested our therapy on this cell type. Earlier research conducted with lung cells and in a cardiac model with the nonsteroidal anti-inflammatory drug (NSAID) sulindac (Moench et al., 2009; Marchetti et al., 2009) indicate that sulindac can protect normal cells from oxidative damage through ischemic preconditioning (IPC) pathways. This led us to test whether sulindac can also protect significant protection against both tert-butyl hydrogen peroxide (TBHP) induced chemical stress and UVB light induced photooxidative damage through a preconditioning mechanism.
Title: Differential effect of sulindac on normal and malignant retinal cells.
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Name(s): Sur, Arunodoy, author
Blanks, Janet C., Thesis advisor
Charles E. Schmidt College of Science, Degree grantor
Center for Complex Systems and Brain Sciences
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Issued: 2013
Publisher: Florida Atlantic University
Physical Form: application/pdf
Extent: 134 p.
Language(s): English
Summary: Age related macular degeneration (AMD) is the leading cause of blindness among the elderly population and oxidative stress induced damage of ocular tissues is thought to play an important role in the etiology of this disease. This current study is aimed at testing pharmacological preconditioning as a possible protective mechanism for retinal cells against oxidative stress induced damage. Since the retinal pigment epithelial (RPE) cells located adjacent to the photoreceptor cells, are believed to be responsible for the initial pathology in AMD we tested our therapy on this cell type. Earlier research conducted with lung cells and in a cardiac model with the nonsteroidal anti-inflammatory drug (NSAID) sulindac (Moench et al., 2009; Marchetti et al., 2009) indicate that sulindac can protect normal cells from oxidative damage through ischemic preconditioning (IPC) pathways. This led us to test whether sulindac can also protect significant protection against both tert-butyl hydrogen peroxide (TBHP) induced chemical stress and UVB light induced photooxidative damage through a preconditioning mechanism.
Identifier: FA00004258 (IID)
Note(s): Includes bibliography.
Dissertation (Ph.D.)--Florida Atlantic University, 2013.
Held by: Florida Atlantic University Digital Library
Sublocation: Boca Raton, Fla.
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00004258
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Host Institution: FAU