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Alternate applications of anticancer drugs on COS-7 normal cells

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Date Issued:
2009
Summary:
Anticancer drugs, including nocodazole and vinblastine, work by disrupting the dynamics of microtubules. Unfortunately, these drugs often produce numerous side effects, including nausea, vomiting, loss of appetite, loss of hair, increased chance of infection, and fatigue. My thesis research evaluated the efficacy of using repeated low doses of microtubule drugs instead of a single high dose, in an attempt to minimize side effects. Using nocodazole and vinblastine, I first established the minimum effective concentration that disrupts the microtubules in normal human cells grown in vitro and treated cells with those concentrations over a period of several days. I found that microtubules were increasingly depolymerized as the days progressed. Next, I tested a combination of nocodazole and vinblastine at low concentrations.
Title: Alternate applications of anticancer drugs on COS-7 normal cells.
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Name(s): Morris, Deborah.
Harriet L. Wilkes Honors College
Type of Resource: text
Genre: Thesis
Issuance: multipart monograph
Date Issued: 2009
Publisher: Florida Atlantic University
Physical Form: electronic
electronic resource
Extent: vi, 16 leaves : ill. (some col.) ; 29 cm.
Language(s): English
Summary: Anticancer drugs, including nocodazole and vinblastine, work by disrupting the dynamics of microtubules. Unfortunately, these drugs often produce numerous side effects, including nausea, vomiting, loss of appetite, loss of hair, increased chance of infection, and fatigue. My thesis research evaluated the efficacy of using repeated low doses of microtubule drugs instead of a single high dose, in an attempt to minimize side effects. Using nocodazole and vinblastine, I first established the minimum effective concentration that disrupts the microtubules in normal human cells grown in vitro and treated cells with those concentrations over a period of several days. I found that microtubules were increasingly depolymerized as the days progressed. Next, I tested a combination of nocodazole and vinblastine at low concentrations.
Identifier: 460167950 (oclc), 209996 (digitool), FADT209996 (IID), fau:1370 (fedora)
Note(s): by Deborah Morris.
Thesis (B.A.)--Florida Atlantic University, Honors College, 2009.
Bibliography: leaf 16.
Electronic reproduction. Boca Raton, Fla., 2009. Mode of access: World Wide Web.
Subject(s): Cancer cells -- Growth -- Regulation
Antineoplastic agents -- Physiological effect
Cell cycle -- Effect of drugs on
Cancer -- Chemotherapy
Held by: FBoU FAUER
Persistent Link to This Record: http://purl.flvc.org/FAU/209996
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Host Institution: FAU

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