You are here

FAU Collections » FAU Research Repository » FAU Student Research » FAU Undergraduate Student Research

Conformational Masking in HIV-1

Download pdf | Full Screen View

Date Issued:
2014
Summary:
Molecular modeling enables an individual to explore the nature of various molecules and the interaction between molecules using only a computer and their fingertips. This computer technology is an expanding field and has a plethora of applications ranging from teaching to the design of new drugs. Molecular modeling allows studying through calculation and visualization of molecular systems varying in size from minute chemical systems to hefty biological ones. The system analyzed in this study is that of gp120, the envelope glycoprotein on HIV-1 essential for viral entry into cells. HIV-1’s invasive success can be attributed to its ability to conformationally mask itself from the immune system. It achieves this because of the highly glycosylated surface of gp120. Using HyperChem Release 7, Visual Molecular Dynamics (VMD) 1.9.1, and NAMD 2.9, the glycosylated surface of gp120 and its molecular dynamics were examined to confirm its effectiveness.
Title: Conformational Masking in HIV-1.
139 views
18 downloads
Name(s): Goordeen, Ashley
Snyder, Patricia Ann
Type of Resource: text
Genre: Poster
Date Issued: 2014
Publisher: Florida Atlantic University Digital Library
Physical Form: Online Resource
Extent: 1 p.
Language(s): English
Summary: Molecular modeling enables an individual to explore the nature of various molecules and the interaction between molecules using only a computer and their fingertips. This computer technology is an expanding field and has a plethora of applications ranging from teaching to the design of new drugs. Molecular modeling allows studying through calculation and visualization of molecular systems varying in size from minute chemical systems to hefty biological ones. The system analyzed in this study is that of gp120, the envelope glycoprotein on HIV-1 essential for viral entry into cells. HIV-1’s invasive success can be attributed to its ability to conformationally mask itself from the immune system. It achieves this because of the highly glycosylated surface of gp120. Using HyperChem Release 7, Visual Molecular Dynamics (VMD) 1.9.1, and NAMD 2.9, the glycosylated surface of gp120 and its molecular dynamics were examined to confirm its effectiveness.
Identifier: FA0005020 (IID)
Subject(s): College students --Research --United States.
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA0005020
Host Institution: FAU