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effects of cocaine pre-exposure and maternal deprivation in the self-administration of cocaine and amphetamine in neonatal rats

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Date Issued:
1999
Summary:
The effects of cocaine exposure and maternal deprivation on subsequent voluntary ingestion of cocaine and amphetamine was investigated in 7-day-old rat pups in order to further our understanding on the development of drug addiction. Maternally deprived and non-deprived pups were pre-exposed to a cocaine solution masked with 5% orange Tang solution. Four hours later, experimental pups were tested for subsequent cocaine self-administration (SA) (Exp. 1) or amphetamine SA, (Exp. 2), following a second deprivation period. Control pups were not deprived during this interval. Pups in both experiments were assessed for dose self-administered and for general activity. Results indicate that cocaine pre-exposure increased cocaine and amphetamine SA, and activity significantly increased after pre-exposure and testing sessions. Lastly, sensitization of the motor effects of cocaine was observed in pups pre-exposed to cocaine. This study provides a potential drug SA animal model not yet investigated in developing animals.
Title: The effects of cocaine pre-exposure and maternal deprivation in the self-administration of cocaine and amphetamine in neonatal rats.
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Name(s): Ungaro, Giovanna Marisol.
Florida Atlantic University, Degree grantor
Terry, Leslie M., Thesis advisor
Johanson, Ingrid B., Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1999
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 65 p.
Language(s): English
Summary: The effects of cocaine exposure and maternal deprivation on subsequent voluntary ingestion of cocaine and amphetamine was investigated in 7-day-old rat pups in order to further our understanding on the development of drug addiction. Maternally deprived and non-deprived pups were pre-exposed to a cocaine solution masked with 5% orange Tang solution. Four hours later, experimental pups were tested for subsequent cocaine self-administration (SA) (Exp. 1) or amphetamine SA, (Exp. 2), following a second deprivation period. Control pups were not deprived during this interval. Pups in both experiments were assessed for dose self-administered and for general activity. Results indicate that cocaine pre-exposure increased cocaine and amphetamine SA, and activity significantly increased after pre-exposure and testing sessions. Lastly, sensitization of the motor effects of cocaine was observed in pups pre-exposed to cocaine. This study provides a potential drug SA animal model not yet investigated in developing animals.
Identifier: 9780599540743 (isbn), 15745 (digitool), FADT15745 (IID), fau:12734 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Thesis (M.A.)--Florida Atlantic University, 1999.
Charles E. Schmidt College of Science
Subject(s): Cocaine--Physiological effect
Amphetamines--Physiological effect
Rats as laboratory animals
Maternal deprivation
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/15745
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.