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synthesis of chitosan-cis-DDP derivative
| Title: | The synthesis of chitosan-cis-DDP derivative. |
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| Name(s): |
Francis, Ann-Marie Florida Atlantic University, Degree Grantor Louda, Deborah W., Thesis Advisor Carraher, Charles E., Thesis Advisor |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 1999 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 73 p. | |
| Language(s): | English | |
| Summary: | The formation of polymeric derivatives of the cancer drug Cis-dichlorodiaminoplatinum (II), cis-DDP, by the reaction of (1-4)-2-acetamide-2-deoxy-beta-D-glucose (Chitosan) with potassium tetrachloroplatinate is reported. Chelation of (1-4)-2-acetamide-2-deoxy-beta-D-glucose by tetrachloroplatinum (II) occurred through the amine groups leaving the hydroxyls unreacted and free to assist in making the products water soluble. It was hoped that such compounds would retain the anti tumor activity of cis-DDP but produce fewer toxic side effects. Structural characterization involved infrared spectroscopy, mass spectroscopy, EDAX analytical methods. Products were also analyzed using light scattering photometry, elemental analysis and solubility studies. Additionally, the biological activity of water-soluble products was tested against selected cell lines. | |
| Identifier: | 9780599419155 (isbn), 15699 (digitool), FADT15699 (IID), fau:12455 (fedora) | |
| Note(s): | Thesis (M.S.)--Florida Atlantic University, 1999. | |
| Subject(s): |
Chitosan Polymeric drugs |
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| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/15699 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
