You are here
development of an animal model for attention deficit hyperactivity disorder: Effects of frontal lesions on activity in neonatal rats
| Title: | The development of an animal model for attention deficit hyperactivity disorder: Effects of frontal lesions on activity in neonatal rats. |
 133 views 53 downloads |
|---|---|---|
| Name(s): |
Stevenson, Bernadette Mietus Florida Atlantic University, Degree grantor Johanson, Ingrid B., Thesis advisor Terry, Leslie M., Thesis advisor |
|
| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 1997 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 83 p. | |
| Language(s): | English | |
| Summary: | This study was designed to develop an animal model of Attention Deficit Hyperactivity Disorder based on frontal cortical functioning in 3, 6, 9, & 12-day-old neonatal rats. In Expt. 1, frontal cortical activity was suppressed with intracranial injections of lidocaine, a local anesthetic. In Expt. 2, frontal activity was suppressed with brain transections. Pups in both experiments were tested in a habituation-to-odor learning paradigm and behaviors including general activity, headwaving, probing, and rolling were recorded. Results indicated that frontal cortical suppression, caused by either lidocaine injection or brain transection, resulted in significantly higher activity levels in 3-day-olds particularly with regard to rolling, suggesting that the frontal cortex is involved in the regulation of rolling behavior. Frontal transections, but not lidocaine injections, also significantly increased activity in 12-day-old pups due to increased locomotor probing and wall climbing. Results are consistent with the neuropsychological research regarding frontal cortical functioning and inhibition in children with ADHD, and show potential as a future animal model of ADHD. | |
| Identifier: | 9780591625172 (isbn), 15516 (digitool), FADT15516 (IID), fau:12278 (fedora) | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): |
Thesis (M.A.)--Florida Atlantic University, 1997. Charles E. Schmidt College of Science |
|
| Subject(s): |
Attention-deficit hyperactivity disorder Attention-deficit hyperactivity disorder--Diagnosis |
|
| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/15516 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
