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Tolerance to amphetamine in cannula vs. bottle-fed animals
- Date Issued:
- 1997
- Summary:
- The effects of amphetamine on the milk intake, body weight, and behavioral activity of bottle- and cannula-fed rats was investigated in a before/after paradigm. Dose response determinations were conducted before (DR 1) and after (DR 2) chronic treatment (45 days) with amphetamine (8.0 mg/kg) given either before or after milk tests, to determine whether tolerance developed to the anorexic effect of the drug. Control groups were given saline during the chronic phase. Both cannula- and bottle-fed animals lost a significant amount of weight. Cannula-fed animals drank significantly more than bottle-fed animals throughout the chronic phase. Statistical analysis revealed significant increases in intake from DR 1 to DR 2 for the after and saline cannula-fed groups, and the before, after, and saline bottle-fed groups. All groups showed an increase in intake from DR 1 to DR 2, though the increase of the before cannula-fed group failed to reach statistical significance.
Title: | Tolerance to amphetamine in cannula vs. bottle-fed animals. |
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Name(s): |
Walls, Julie A. Florida Atlantic University, Degree Grantor Wolgin, David L., Thesis Advisor |
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Type of Resource: | text | |
Genre: | Electronic Thesis Or Dissertation | |
Issuance: | monographic | |
Date Issued: | 1997 | |
Publisher: | Florida Atlantic University | |
Place of Publication: | Boca Raton, Fla. | |
Physical Form: | application/pdf | |
Extent: | 48 p. | |
Language(s): | English | |
Summary: | The effects of amphetamine on the milk intake, body weight, and behavioral activity of bottle- and cannula-fed rats was investigated in a before/after paradigm. Dose response determinations were conducted before (DR 1) and after (DR 2) chronic treatment (45 days) with amphetamine (8.0 mg/kg) given either before or after milk tests, to determine whether tolerance developed to the anorexic effect of the drug. Control groups were given saline during the chronic phase. Both cannula- and bottle-fed animals lost a significant amount of weight. Cannula-fed animals drank significantly more than bottle-fed animals throughout the chronic phase. Statistical analysis revealed significant increases in intake from DR 1 to DR 2 for the after and saline cannula-fed groups, and the before, after, and saline bottle-fed groups. All groups showed an increase in intake from DR 1 to DR 2, though the increase of the before cannula-fed group failed to reach statistical significance. | |
Identifier: | 9780591624892 (isbn), 15488 (digitool), FADT15488 (IID), fau:12252 (fedora) | |
Note(s): | Thesis (M.A.)--Florida Atlantic University, 1997. | |
Subject(s): |
Rats as laboratory animals Drug tolerance Drugs--Physiological effect Amphetamines--Physiological effect |
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Held by: | Florida Atlantic University Libraries | |
Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/15488 | |
Sublocation: | Digital Library | |
Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
Host Institution: | FAU | |
Is Part of Series: | Florida Atlantic University Digital Library Collections. |