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Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia

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Date Issued:
1996
Summary:
The purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was available. After a 4 wk drug withdrawal period, both groups lost tolerance and displayed more intense stereotypy than they had prior to drug withdrawal. Therefore, sensitization of stereotypy did not retard the development of tolerance. However, the loss of tolerance following drug withdrawal may have been due to the development of more intense stereotypy and/or the "unlearning" of previously acquired strategies for suppressing stereotypy.
Title: Effect of prior sensitization of stereotypy on the acquisition and retention of tolerance to amphetamine hypophagia.
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Name(s): Hughes, Katherine M.
Florida Atlantic University, Degree Grantor
Wolgin, David L., Thesis Advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1996
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 62 p.
Language(s): English
Summary: The purpose of this study was to determine whether prior sensitization of stereotypy interferes with the development and retention of tolerance to amphetamine-induced hypophagia. Rats were given intermittent injections of either amphetamine to induce sensitization of stereotypy, or saline. Both sensitized and nonsensitized groups became tolerant to drug-induced hypophagia to the same degree. Such tolerance was accompanied by a decrease in the frequency of stereotyped movements while milk was available. After a 4 wk drug withdrawal period, both groups lost tolerance and displayed more intense stereotypy than they had prior to drug withdrawal. Therefore, sensitization of stereotypy did not retard the development of tolerance. However, the loss of tolerance following drug withdrawal may have been due to the development of more intense stereotypy and/or the "unlearning" of previously acquired strategies for suppressing stereotypy.
Identifier: 15287 (digitool), FADT15287 (IID), fau:12058 (fedora)
Note(s): Thesis (M.A.)--Florida Atlantic University, 1996.
Subject(s): Drug tolerance
Drugs--Physiological effect
Amphetamines--Physiological effect
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/15287
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.