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Biosynthetic studies of the antitumor ecteinascidins in the marine tunicate Ecteinascidia turbinata

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Date Issued:
1996
Summary:
Ecteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have also been identified. These preliminary experiments set the stage for subsequent protein isolation.
Title: Biosynthetic studies of the antitumor ecteinascidins in the marine tunicate Ecteinascidia turbinata.
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Name(s): Miranda, Neil Fermino
Florida Atlantic University, Degree Grantor
Kerr, Russell G., Thesis Advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1996
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 72 p.
Language(s): English
Summary: Ecteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have also been identified. These preliminary experiments set the stage for subsequent protein isolation.
Identifier: 15242 (digitool), FADT15242 (IID), fau:12013 (fedora)
Note(s): Thesis (M.S.)--Florida Atlantic University, 1996.
Subject(s): Tunicata
Marine pharmacology
Biological assay
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/15242
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
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Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.