You are here

FAU Collections » FAU Research Repository » FAU Theses and Dissertations

response of rat retinal ganglion cells to axotomy: Early changes in the regulation of fast transported proteins

Download pdf | Full Screen View

Date Issued:
1994
Summary:
Mammals, unlike lower vertebrates, cannot normally regenerate injured central nervous system neurons. Although rat retinal ganglion cells (RGCs), following optic nerve crush, will undergo an initial period of sprouting, axon outgrowth is limited and subsequently aborted. This study examined how extensive the changes in fast transported proteins (FTPs) were during the early response to RGC damage and whether these changes were comparable to those known to occur in lower vertebrate RGCs. Changes in mRNA for several known proteins were also analyzed. It was found that, within 2 days, axotomized rat RGCs initiated a program of cell growth, involving the differential synthesis and transport of a broad range of FTPs. This response is very similar to that of lower vertebrates and indicates that rat RGCs are capable of initiating the metabolic responses necessary for regeneration to begin. This response, however, was not sustained beyond 5 days axotomy.
Title: The response of rat retinal ganglion cells to axotomy: Early changes in the regulation of fast transported proteins.
89 views
25 downloads
Name(s): Wodarczyk, Linda
Florida Atlantic University, Degree Grantor
Perry, Gary W., Thesis Advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1994
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 149 p.
Language(s): English
Summary: Mammals, unlike lower vertebrates, cannot normally regenerate injured central nervous system neurons. Although rat retinal ganglion cells (RGCs), following optic nerve crush, will undergo an initial period of sprouting, axon outgrowth is limited and subsequently aborted. This study examined how extensive the changes in fast transported proteins (FTPs) were during the early response to RGC damage and whether these changes were comparable to those known to occur in lower vertebrate RGCs. Changes in mRNA for several known proteins were also analyzed. It was found that, within 2 days, axotomized rat RGCs initiated a program of cell growth, involving the differential synthesis and transport of a broad range of FTPs. This response is very similar to that of lower vertebrates and indicates that rat RGCs are capable of initiating the metabolic responses necessary for regeneration to begin. This response, however, was not sustained beyond 5 days axotomy.
Identifier: 15074 (digitool), FADT15074 (IID), fau:11852 (fedora)
Note(s): Thesis (M.A.)--Florida Atlantic University, 1994.
Subject(s): Regeneration (Biology)
Retinal ganglion cells
Rats as laboratory animals
Nerves--Growth
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/15074
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.