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supramammillary nucleus: Does it play a role in the mediation of hippocampal theta rhythm?

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Date Issued:
1993
Summary:
Recent evidence suggests that the supramammillary nucleus (SUM) is an important link from the pontine reticular formation (PRF) to the septum-hippocampus in the generation of hippocampal theta rhythm. I proposed: (1) injections of WGA-HRP into the SUM would produce retrograde labeling in PRF cells; (2) lesions of the SUM would produce a reduction in the frequency and amplitude of hippocampal theta rhythm; (3) injections of procaine into the SUM would attenuate the amplitude and reduce the frequency of reticular elicited theta rhythm. Although WGA-HRP injections in the SUM produced minimal labeling in the PRF, there were labeled cells in the central gray of the pons, and in the dorsal raphe and surrounding regions. I found that lesions of the SUM produced minimal changes in the frequency and amplitude of theta in the behaving animal but that injections of procaine attenuated both of these measures in the urethane anesthetized rat.
Title: The supramammillary nucleus: Does it play a role in the mediation of hippocampal theta rhythm?.
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Name(s): Thinschmidt, Jeffrey Scott.
Florida Atlantic University, Degree grantor
Vertes, Robert P., Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1993
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 103 p.
Language(s): English
Summary: Recent evidence suggests that the supramammillary nucleus (SUM) is an important link from the pontine reticular formation (PRF) to the septum-hippocampus in the generation of hippocampal theta rhythm. I proposed: (1) injections of WGA-HRP into the SUM would produce retrograde labeling in PRF cells; (2) lesions of the SUM would produce a reduction in the frequency and amplitude of hippocampal theta rhythm; (3) injections of procaine into the SUM would attenuate the amplitude and reduce the frequency of reticular elicited theta rhythm. Although WGA-HRP injections in the SUM produced minimal labeling in the PRF, there were labeled cells in the central gray of the pons, and in the dorsal raphe and surrounding regions. I found that lesions of the SUM produced minimal changes in the frequency and amplitude of theta in the behaving animal but that injections of procaine attenuated both of these measures in the urethane anesthetized rat.
Identifier: 14919 (digitool), FADT14919 (IID), fau:11701 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Thesis (M.A.)--Florida Atlantic University, 1993.
Charles E. Schmidt College of Science
Subject(s): Theta rhythm
Hippocampus (Brain)
Memory
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14919
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
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Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.