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Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia

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Date Issued:
1992
Summary:
It was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is, sensitized animals were not impaired on milk intake, whereas nonsensitized animals became more sensitive to the hypophagic effect of amphetamine. Further, it was found that animals sensitized to the stereotyped behavioral effects of the drug developed tolerance to this effect, and this tolerance was found to occur both in the presence and absence of milk.
Title: Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine induced hypophagia.
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Name(s): Kinney, Gene G.
Florida Atlantic University, Degree grantor
Wolgin, David L., Thesis advisor
Charles E. Schmidt College of Science
Department of Psychology
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1992
Physical Form: application/pdf
Extent: 57 p.
Language(s): English
Summary: It was hypothesized that animals sensitized to the stereotyped behavioral effects of amphetamine would have a more difficult time developing tolerance to the hypophagic effect of the drug than nonsensitized animals. Although sensitized animals showed more intense stereotypy, they were not impaired in the development of tolerance, or in the amount of tolerance gained, thus showing a dissociation between these two variables. Differential sensitization was also shown to these effects. That is, sensitized animals were not impaired on milk intake, whereas nonsensitized animals became more sensitive to the hypophagic effect of amphetamine. Further, it was found that animals sensitized to the stereotyped behavioral effects of the drug developed tolerance to this effect, and this tolerance was found to occur both in the presence and absence of milk.
Identifier: 14792 (digitool), FADT14792 (IID), fau:11581 (fedora)
Degree granted: Thesis (M.A.)--Florida Atlantic University, 1992.
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Charles E. Schmidt College of Science
Subject(s): Drug tolerance
Drugs--Physiological effect
Amphetamines--Physiological effect
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14792
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.