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Limited influence of Pavlovian conditioning on tolerance to the anorexic effect of morphine

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Date Issued:
1990
Summary:
Rats that developed tolerance to the anorexic effect of morphine under conditions supportive of associational tolerance were tested for Pavlovian conditioned tolerance. Initially sensitive and nonsensitive rats received chronic morphine injections of 10 and 20mg/kg respectively in the presence of an explicitly paired compound cue until tolerant to the morphine induced suppression of milk intake. In a test for compensatory responding, only nonsensitive rats increased their intake in response to a placebo injection of saline in the presence of the morphine cue. In tests of associative tolerance, morphine injections in the presence of an explicitly unpaired saline cue, or in the absence of either cue, did not produce a loss of tolerance. After the temporal pattern of morphine administration was extinguished, only nonsensitive rats showed both a loss of tolerance in the presence of the saline cue, and tolerance retention in the presence of the morphine cue.
Title: Limited influence of Pavlovian conditioning on tolerance to the anorexic effect of morphine.
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Name(s): Benson, Henry Donald, Jr.
Florida Atlantic University, Degree grantor
Wolgin, David L., Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1990
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 69 p.
Language(s): English
Summary: Rats that developed tolerance to the anorexic effect of morphine under conditions supportive of associational tolerance were tested for Pavlovian conditioned tolerance. Initially sensitive and nonsensitive rats received chronic morphine injections of 10 and 20mg/kg respectively in the presence of an explicitly paired compound cue until tolerant to the morphine induced suppression of milk intake. In a test for compensatory responding, only nonsensitive rats increased their intake in response to a placebo injection of saline in the presence of the morphine cue. In tests of associative tolerance, morphine injections in the presence of an explicitly unpaired saline cue, or in the absence of either cue, did not produce a loss of tolerance. After the temporal pattern of morphine administration was extinguished, only nonsensitive rats showed both a loss of tolerance in the presence of the saline cue, and tolerance retention in the presence of the morphine cue.
Identifier: 14672 (digitool), FADT14672 (IID), fau:11464 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Charles E. Schmidt College of Science
Thesis (M.S.)--Florida Atlantic University, 1990.
Subject(s): Classical conditioning
Drug tolerance
Morphine
Appetite--Effect of drugs on
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14672
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.