You are here

FAU Collections » FAU Research Repository » FAU Theses and Dissertations

Inhibition of DNA synthesis by platinum (II) polyamines

Download pdf | Full Screen View

Date Issued:
1989
Summary:
Cis-DDP is a chemotherapeutic drug which has been very useful in the treatment of testicular and ovarian cancers. Recently, polymeric drugs modeled after cis-DDP have been developed by reacting potassium tetrachloroplatinate with various diamines. Previous testing of these analogs on cells indicated that many were cytotoxic. To see if the cytotoxic effects were the result of inhibition of DNA synthesis as is thought to be the case for cis-DDP, 3H-thymidine incorporation studies were carried out on polymer-treated cells. The results were compared to incorporation studies from cis-DDP-treated cells and found to be similar. The results from the DNA synthesis studies were compared to cytotoxic results, and they indicated that inhibition of DNA synthesis may be responsible for the cytotoxic effects of the polymers. The size of a polymer was found to be unimportant in determining its effectiveness.
Title: Inhibition of DNA synthesis by platinum (II) polyamines.
69 views
15 downloads
Name(s): Colvin, Alex Charles.
Florida Atlantic University, Degree grantor
Siegmann, Deborah, Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1989
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 152 p.
Language(s): English
Summary: Cis-DDP is a chemotherapeutic drug which has been very useful in the treatment of testicular and ovarian cancers. Recently, polymeric drugs modeled after cis-DDP have been developed by reacting potassium tetrachloroplatinate with various diamines. Previous testing of these analogs on cells indicated that many were cytotoxic. To see if the cytotoxic effects were the result of inhibition of DNA synthesis as is thought to be the case for cis-DDP, 3H-thymidine incorporation studies were carried out on polymer-treated cells. The results were compared to incorporation studies from cis-DDP-treated cells and found to be similar. The results from the DNA synthesis studies were compared to cytotoxic results, and they indicated that inhibition of DNA synthesis may be responsible for the cytotoxic effects of the polymers. The size of a polymer was found to be unimportant in determining its effectiveness.
Identifier: 14547 (digitool), FADT14547 (IID), fau:11344 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Thesis (M.S.)--Florida Atlantic University, 1989.
Charles E. Schmidt College of Science
Subject(s): DNA--Synthesis
Cisplatin--Physiological effect
Platinum compounds--Physiological effect
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14547
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.