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Chemistry and biological activity of platinum (II) polyamines

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Date Issued:
1988
Summary:
One of the most common chemotherapeutic drugs in use today is cis-DDP. While this substance has been found useful in the treatment of various malignant neoplasias, it also has many adverse side effects. Recently, polymeric cis-DDP analogs have been prepared using potassium tetrachloroplatinate and various diamines. Testing of these polymeric analogs has shown that some are biologically active while others are biologically inactive. The goal of this research was to investigate the possible reasons for the differences in biological activity which had been observed. The biological activity of the diamine components, the molecular weight of the polymers, and the degradation of the polymers were examined to determine if any of these properties of the polymers could be correlated to their biological activities.
Title: Chemistry and biological activity of platinum (II) polyamines.
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Name(s): Brenner, Dora Lynn.
Florida Atlantic University, Degree grantor
Louda, Deborah W., Thesis advisor
Carraher, Charles E., Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1988
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: pdf
Extent: 124 p.
Language(s): English
Summary: One of the most common chemotherapeutic drugs in use today is cis-DDP. While this substance has been found useful in the treatment of various malignant neoplasias, it also has many adverse side effects. Recently, polymeric cis-DDP analogs have been prepared using potassium tetrachloroplatinate and various diamines. Testing of these polymeric analogs has shown that some are biologically active while others are biologically inactive. The goal of this research was to investigate the possible reasons for the differences in biological activity which had been observed. The biological activity of the diamine components, the molecular weight of the polymers, and the degradation of the polymers were examined to determine if any of these properties of the polymers could be correlated to their biological activities.
Identifier: 14469 (digitool), FADT14469 (IID), fau:11268 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Thesis (M.S.)--Florida Atlantic University, 1988.
Charles E. Schmidt College of Science
Subject(s): Polyamines--Physiological effect
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14469
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.