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EFFECTIVENESS OF ANTI-HERPETIC COMPOUNDS ON PACHECO'S DISEASE VIRUS OF PSITTACINES

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Date Issued:
1983
Summary:
Three antiviral compounds, 5-iodo-2' -deoxyuridine (IUDR), 9-(2-hydroxyethoxymethyl )guanine (acyclovir) and methylglyoxal-bis-(guanylhydrazone) MGBG were tested for their effectiveness against Pacheco's disease virus (PDV). IUDR caused a fifty percent reduction in plaque formation (PR50) at 0 .8 μM in chicken embryo fibroblasts while acyclovir showed a PR50 of 6.6 μM. Plaque inhibition assays showed a significant decrease in plaque size (1.25 mm to 0.45 mm) at 10 μM acyclovir and (1.3 mm to 0.5 mm) at both 1 μM and 10 μM of IUDR. MGBG did not reduce virus replication vitro, and an apparent reduction of virus growth in vivo was probably due to toxicity. However, in vitro toxicity studies did not show any significant reduction in cell growth with any of the compounds tested.
Title: EFFECTIVENESS OF ANTI-HERPETIC COMPOUNDS ON PACHECO'S DISEASE VIRUS OF PSITTACINES.
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Name(s): AVERY, PATRICIA OTTENS.
Florida Atlantic University, Degree grantor
Hartmann, James X., Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1983
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 89 p.
Language(s): English
Summary: Three antiviral compounds, 5-iodo-2' -deoxyuridine (IUDR), 9-(2-hydroxyethoxymethyl )guanine (acyclovir) and methylglyoxal-bis-(guanylhydrazone) MGBG were tested for their effectiveness against Pacheco's disease virus (PDV). IUDR caused a fifty percent reduction in plaque formation (PR50) at 0 .8 μM in chicken embryo fibroblasts while acyclovir showed a PR50 of 6.6 μM. Plaque inhibition assays showed a significant decrease in plaque size (1.25 mm to 0.45 mm) at 10 μM acyclovir and (1.3 mm to 0.5 mm) at both 1 μM and 10 μM of IUDR. MGBG did not reduce virus replication vitro, and an apparent reduction of virus growth in vivo was probably due to toxicity. However, in vitro toxicity studies did not show any significant reduction in cell growth with any of the compounds tested.
Identifier: 14145 (digitool), FADT14145 (IID), fau:10958 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Thesis (M.S.)--Florida Atlantic University, 1983.
Charles E. Schmidt College of Science
Subject(s): Herpesviruses
Birds--Diseases
Psittacosis
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14145
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.