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REVERSAL OF FORELIMB PLACING DEFICITS WITH CORTICAL SPREADING DEPRESSION

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Date Issued:
1981
Summary:
Rats with lesions of the ventromedial aspect of the internal capsule in the vicinty of the entopeduncular nucleus (EP) showed a loss of forelimb placing (chin, contact and visual) in the contralateral limb. Spreading depression induced by instillation of KCl (25%) to the cortex contralateral to the lesion brought back placing in the affected limb and abolished placing in the normal limb. Within 24 hours the pre-spreading depression state returned and the impaired limb no longer placed while the normal limb recovered function. In contrast, KCl on the ipsilateral cortex did not reinstate placing. These results suggest that the loss of placing following lesions of the EP are due to tonic inhibition from the cortex contralateral to the lesion. Sensory summation was evident during the early recovery period when placing was accomplished only if two kinds of stimuli were provided simultaneously. Forelimb placing recovered to its pre-lesion state.
Title: REVERSAL OF FORELIMB PLACING DEFICITS WITH CORTICAL SPREADING DEPRESSION.
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Name(s): Kehoe, Priscilla
Florida Atlantic University, Degree grantor
Wolgin, David L., Thesis advisor
Charles E. Schmidt College of Science
Department of Psychology
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 1981
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, FL
Physical Form: application/pdf
Extent: 53 p.
Language(s): English
Summary: Rats with lesions of the ventromedial aspect of the internal capsule in the vicinty of the entopeduncular nucleus (EP) showed a loss of forelimb placing (chin, contact and visual) in the contralateral limb. Spreading depression induced by instillation of KCl (25%) to the cortex contralateral to the lesion brought back placing in the affected limb and abolished placing in the normal limb. Within 24 hours the pre-spreading depression state returned and the impaired limb no longer placed while the normal limb recovered function. In contrast, KCl on the ipsilateral cortex did not reinstate placing. These results suggest that the loss of placing following lesions of the EP are due to tonic inhibition from the cortex contralateral to the lesion. Sensory summation was evident during the early recovery period when placing was accomplished only if two kinds of stimuli were provided simultaneously. Forelimb placing recovered to its pre-lesion state.
Identifier: 14078 (digitool), FADT14078 (IID), fau:10893 (fedora)
Degree granted: Thesis (M.A.)--Florida Atlantic University, 1981.
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Charles E. Schmidt College of Science
Subject(s): Rats--Physiology
Neural circuitry
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/14078
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.