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THE ROLE OF THE PARATENIAL NUCLEUS AND NUCLEUS REUNIENS OF THE MIDLINE THALAMUS IN COGNITION AND AFFECT
| Title: | THE ROLE OF THE PARATENIAL NUCLEUS AND NUCLEUS REUNIENS OF THE MIDLINE THALAMUS IN COGNITION AND AFFECT. |
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| Name(s): |
Rojas, Amanda Katherine Pajor , author Vertes, Robert P. , Thesis advisor Florida Atlantic University, Degree grantor Center for Complex Systems and Brain Sciences Charles E. Schmidt College of Science |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2024 | |
| Date Issued: | 2024 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 228 p. | |
| Language(s): | English | |
| Abstract/Description: | The midline nuclei of the thalamus, previously characterized as “nonspecific” with undifferentiated connections with the cortex, have been shown to distribute in a specific and highly organized manner to subcortical and cortical structures. The midline thalamus consists of the paraventricular (PV) and paratenial (PT) nuclei, dorsally, and the reuniens (RE) and rhomboid (RH) nuclei, ventrally. The PV and RE nuclei have been examined to a far greater extent than either the PT or RH and have been shown to be involved in various affective and cognitive functions. Generally, PV is more associated with emotional and motivated behaviors such as arousal, feeding, drug addiction, fear, and anxiety, whereas RE is more involved in cognitive and mnemonic functions -- as RE represents a critical bridge between the medial prefrontal cortex (mPFC) and the hippocampal formation. As afferent projections to PT have not been systemically described, we examined the input to PT comparing it with that to PV, using retrograde anatomical tracer, fluorogold (FG). We found PT and PV are almost exclusively targeted by ‘limbic’ structures of the forebrain. Whereas afferents to PT and PV originate from very similar sources, PT receives stronger input from the cortex and PV from subcortical structures. Notably, PT receives prominent input from the mPFC and orbital (ORB) cortices, two regions associated with cognitive flexibility and decision making. | |
| Identifier: | FA00014505 (IID) | |
| Degree granted: | Dissertation (PhD)--Florida Atlantic University, 2024. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Cognition Thalamus Affect |
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| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00014505 | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
